diff --git a/drivers/i2c/busses/i2c-stm32f7.c b/drivers/i2c/busses/i2c-stm32f7.c
index e84e2bec6ca71..0f0c41174dddc 100644
--- a/drivers/i2c/busses/i2c-stm32f7.c
+++ b/drivers/i2c/busses/i2c-stm32f7.c
@@ -1394,6 +1394,7 @@ static irqreturn_t stm32f7_i2c_isr_event(int irq, void *data)
 {
 	struct stm32f7_i2c_dev *i2c_dev = data;
 	struct stm32f7_i2c_msg *f7_msg = &i2c_dev->f7_msg;
+	struct stm32_i2c_dma *dma = i2c_dev->dma;
 	void __iomem *base = i2c_dev->base;
 	u32 status, mask;
 	int ret = IRQ_HANDLED;
@@ -1418,6 +1419,10 @@ static irqreturn_t stm32f7_i2c_isr_event(int irq, void *data)
 	if (status & STM32F7_I2C_ISR_NACKF) {
 		dev_dbg(i2c_dev->dev, "<%s>: Receive NACK\n", __func__);
 		writel_relaxed(STM32F7_I2C_ICR_NACKCF, base + STM32F7_I2C_ICR);
+		if (i2c_dev->use_dma) {
+			stm32f7_i2c_disable_dma_req(i2c_dev);
+			dmaengine_terminate_all(dma->chan_using);
+		}
 		f7_msg->result = -ENXIO;
 	}
 
@@ -1433,7 +1438,7 @@ static irqreturn_t stm32f7_i2c_isr_event(int irq, void *data)
 		/* Clear STOP flag */
 		writel_relaxed(STM32F7_I2C_ICR_STOPCF, base + STM32F7_I2C_ICR);
 
-		if (i2c_dev->use_dma) {
+		if (i2c_dev->use_dma && !f7_msg->result) {
 			ret = IRQ_WAKE_THREAD;
 		} else {
 			i2c_dev->master_mode = false;
@@ -1446,7 +1451,7 @@ static irqreturn_t stm32f7_i2c_isr_event(int irq, void *data)
 		if (f7_msg->stop) {
 			mask = STM32F7_I2C_CR2_STOP;
 			stm32f7_i2c_set_bits(base + STM32F7_I2C_CR2, mask);
-		} else if (i2c_dev->use_dma) {
+		} else if (i2c_dev->use_dma && !f7_msg->result) {
 			ret = IRQ_WAKE_THREAD;
 		} else if (f7_msg->smbus) {
 			stm32f7_i2c_smbus_rep_start(i2c_dev);